An interface phenomenon appears to operate in a phasic fashion with regard to interactivity
between processes of hyperplasia and neoplastic transformation. It is significant that such a process is
not simply one of continuum, but would implicate a realization of systems of operability inbuilt within
network pathways of generation of cellular proliferative activity per se. In this sense, the breast
fibroadenoma is an adaptive lesion to such operative proliferation of epithelial and stromal cell
elements both within the context of other lesions such as fibrocystic disease or as a purely hyperplastic
phenomenon in its own right.
Keywords: interface, permutation, genotoxicity, transformation.
