Christopher A. Lipinski formulated a rule based on his observation that most
drugs administered orally are relatively small and moderately lipophilic molecules.
This rule serves as a guideline to determine whether a molecule with specific
pharmacological or biological activity possesses properties that would make it a viable
orally active drug in humans. Lipinski's Rule of Five functions as a powerful screening
tool in the initial phases of drug discovery, enabling researchers to pick molecules with
ideal attributes for subsequent development and testing.
Keywords: Absorption, Acceptors, Biological activity, Donors, Exceptions drugability, Lipinski’s rule of five.
