This chapter delves into the multifaceted applications of 2-Deoxy-d-Glucose
(2-DG) and its derivatives as versatile tools in diagnostics and therapeutics.
Highlighting their dual role in the medical landscape, this chapter provides a
comprehensive overview of the diverse functions and mechanisms by which these
compounds contribute to both diagnostic assessments and therapeutic interventions.
The first section examines the use of 2-DG and its derivatives in diagnostics, detailing
their efficacy in various imaging techniques, diagnostic assays, and investigative
procedures. Their unique properties and specific interactions in these contexts were
explored to elucidate their significance in the accurate detection and visualization of
specific physiological conditions or anomalies. The subsequent segment shifts the
focus towards the therapeutic realm, where the book chapter investigates the potential
and current applications of 2-DG and its derivatives in treating a spectrum of diseases
and conditions. From their roles in cancer therapy to neurological disorders and severe
acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) treatment, the
chapter outlines the mechanisms and clinical advancements where these compounds
show promise as therapeutic agents. Throughout this discussion, the chapter
emphasizes the evolving landscape of 2-DG and its derivatives, touching upon ongoing
research, challenges, and future prospects in harnessing their dual attributes for
enhanced healthcare outcomes. The exploration of these compounds in both diagnostic
and therapeutic realms not only illuminates their versatility but also underlines the
potential for innovative and integrated medical approaches.
Keywords: Cancer therapy, Neurological disorders, SARS-CoV-2 treatment, Warburg effect, 2-Deoxy-D-Glucose.
