Many synthetic procedures for preparing 2-deoxy-D-glucose (2DG) are
available in the literature. The synthesis of 2DG involves the modification of glucose at
2-position. Several methods to synthesize 2DG include glucose nitrosation and
reductive amination of 2-deoxy-D-arabinose. These methods are highly efficient and
produce high yields of 2DG. This chapter discusses various methods for synthesizing
2DG and their advantages and disadvantages. This chapter describes the different
approaches for synthesizing 2DG and how the choice of method affects its purity,
yield, and properties.
Keywords: Deoxy-D-glucose, Synthetic procedures.
