Traditional medical systems are evolving through technological
advancements, with numerous scientific experiments in genomics, proteomics,
transcriptomics, and pathway analysis driving discoveries in health-related issues. The
primary physiological role of the kidney is the elimination of metabolic waste products
and the regulation of homeostasis within the body. Renal dysfunction, characterized by
the impairment of these vital functions, precipitates severe complications. Dialysis
serves as a therapeutic intervention to ameliorate renal failure by effectively extricating
waste products and surplus fluids from the bloodstream. Though dialysis helps in
treating renal failure, it cannot cure it completely. Although synthetic drugs are not
fully successful, the old medicinal system offers new paths for scientific investigations.
The herbs Aerva lanata and Aerva javanica have a plethora of information about
folkloric traditions and traditional characteristics of therapeutically relevant
medications. The genes responsible for kidney failure are collected from NCBI and
GEO databases. The network is constructed using STRING, and hub genes are
identified from Cytoscape. These hub genes show valid interaction with compounds of
A. lanata and A. javanica herbs than the synthetic compounds that are used in treating
kidney failure. Further, the gene expression, survival and pathways are analyzed, and
experiments are carried out for clinical trials. There are still numerous opportunities for
researchers, practitioners, and professionals in this sector to preserve conventional
healthcare systems and contribute to their future growth.
Keywords: Aerva lanata, Aerva javanica, Genomics, Kidney failure, Pathways.
