The contamination of aflatoxin (AF) in animal diets manifests harmful
effects on animal health and productivity. The effect of ethanolic leaf extracts of
Solanum americanum in rat diet against aflatoxicosis has been discussed. All
hematological and biochemical parameters of AF-alone treated rats were significantly
changed when compared to normal diet-treated ones. The obtained results indicated
that the administration of the leaf extract of S. americanum to aflatoxicated rats
improved the hematological and biochemical parameters toward their respective
normal value. Molecular docking studies have been undertaken for the
phytoconstituents reported for this plant against two cancers and inflammation-related
protein targets. The results of this study indicated that S. americanum has the
possibility of serving as an easily obtainable natural antiaflatoxigenic source for food
supplements or the pharmaceutical sector.
Keywords: Aflatoxin, Antiaflatoxigenic, Molecular docking, Rat diet, Solanum americanum.
