The well-known inflammatory and autoimmune condition known as
systemic lupus erythematosus (SLE) causes symptoms in the kidneys, the skin, the
brain, and the heart. It can also cause complications that affect several organs. The
diversity in organ involvement and heterogeneous conditions of patients led to the
complicated management of SLE. Increasingly, there is evidence highlighting the
importance of phytochemicals in both dietary and non-dietary contexts in the
management of SLE without side effects.
Herein, we discuss the role of different plant extracts with their metabolites and their
modes of action against SLE updated to 2023, in addition to the incorporation of herbal
formulas in the management of the SLE. The present work is an overview of different
plant extracts and their secondary metabolites with significant anti-inflammatory,
antioxidant, and immunomodulation in SLE. The current chapter focuses on the various
targets, mechanisms, and pathways of natural products that manage SLE. Based on the
current work, it can be inferred that natural products show potential as effective agents
in the medical care of SLE.
Keywords: Autoimmune, Anti-inflammatory, Diet, Herbalism, Immunomodulation, Mode of action, Natural compounds, Plant extract, Systemic lupus erythematosus, Treatment.
