Chronic lower back pain significantly contributes to disability within the
musculoskeletal system, affecting a substantial portion of the global population.
Among the numerous factors contributing to chronic back pain, degenerative disc
disease plays a prominent role, particularly in the aging population. It is hypothesized
that the sinuvertebral and basivertebral nerves are the primary mediators of the
nociceptive response observed in degenerative disc disease, resulting from the
neurotization of these nerves. Extensive research has been conducted to explore the
pathoanatomy, pathophysiology, and pain generation pathways involved in
degenerative disc disease and chronic back pain. In this book chapter, the authors
describe management strategies for sinuvertebral and basivertebral neuropathy and
related low back pain symptoms. By examining the current literature, a better
understanding of the treatment options and approaches for addressing this condition
can be attained.
Keywords: Spondylosis, Sinuvertebral nerve, Basivertebral nerve, Discogenic back pain, The pathophysiology of back pain, And endoscopic spine surgery.
