Perovskite materials are becoming more popular in biomedical applications,
notably bone tissue engineering and regenerative medicine. Their distinct physical
features, such as high dielectric constant, ambipolar charge transfer, and
ferroelectricity, make them ideal for bone regeneration. Perovskite-based scaffolds may
replicate bone tissue's extracellular matrix and encourage cell behavior, hence aiding
bone tissue regeneration. These materials have the potential to completely transform
bone defect and injury therapy in regenerative medicine. However, issues like
degradation, scalability, toxicity, device interaction, and cost must be solved before
they can be widely used. To overcome these challenges, it is necessary to improve
stability, scalability, and repeatability, reduce toxicity, achieve device compatibility,
reduce manufacturing costs, and develop standardized testing and safety norms. To
completely understand the biocompatibility and long-term effectiveness of perovskite
materials in bone treatment, further studies and development are required. Despite
these difficulties, perovskite materials offer promise in the treatment of bone
abnormalities and fractures by acting as scaffolds for bone regeneration, medication
delivery vehicles, and imaging agents. Overall, perovskite materials have the potential
to improve bone regeneration and advance musculoskeletal disease therapies.
Keywords: Bone regeneration and growth, Biocompatibility, Cytotoxicity and immunological responses, Osseointegration, Perovskite materials, Strategies, Safety consideration.
