With the advancement of supramolecular chemistry in the realm of sensing,
researchers across the globe have developed various evolutionary extensions of IDAs
from time to time. These comprise enantioselective indicator displacement assays (eIDAs), intramolecular indicator displacement assays (I-IDAs), indicator catalyst
displacement assays (ICDA), reaction-based indicator displacement assays (R-IDAs),
mechanically controlled indicator displacement assays (MC-IDAs), allosteric indicator
displacement assays (A-IDAs), catalytic chemosensing assay (CCA), dimer dye
assembly assay (DDA), and quencher displacement assay (QDA). All these
evolutionary extensions of IDAs have been discussed in detail from concept to
applications along with the possible future outcomes. The authors are of the viewpoint
that this chapter will develop a better understanding of the researchers worldwide in the
context of the advancement of IDAs.
Keywords: Analyte, Allosteric, Chiral analyte, Catalyst, Coordination, Dye, Displacement, Extensions, Enantiomer, Enantiomeric excess, Intramolecular indicator, Mechanical force, Optical signal, Quencher, Receptor, Recognition, Sensing, Signal modulation.
