As a sub-class of colorimetric indicator displacement assays (C-IDAs) as
well as fluorimetric indicator displacement assays (F-IDAs), metal indicator
displacement assays (M-IDAs) involve primarily the coordination of metal ions with a
target receptor and subsequent coordination of colorimetric or fluorimetric indicator
with complexed metal ions and also with the target receptor. The chronological
addition of an interested analyte brings the displacement of the colorimetric or
fluorimetric indicator from the metal ion and the receptor, which in turn illustrates the
binding affair either through colorimetric or fluorescence Turn-ON/OFF response. The
authors have illustrated the role of M-IDAs in the detection of various indispensable
analytes through a vast number of examples and deduced their need in various domains
from future perspectives. The authors are of the opinion that this chapter will bring new
dimensions to metal coordination chemistry in general and sensor development in
particular.
Keywords: Aminoacid sensing, Analyte, Anion sensing, Biomolecules, Binding, Biothiol recognition, Colorimetric response, Complexation, Detection, Fluorescence response, Fluorescence recovery, Interference, Metal indicator displacement assay, Metal-coordination, Macrocyclic receptors, Quantification, Quenching, Sensing ensemble, Selective detection.
