Owing to the ease in their usage and versatility, fluorescent chemosensors
have attracted the remarkable attention of researchers across the globe. In fact, the
dawn of supramolecular chemistry has begun a new journey in the design, construction,
and development of diverse fluorescent chemosensors. Fluorescent indicator
displacement assays (F-IDAs) in principle utilize fluorescent indicators and emission
phenomenon for the construction of various IDA-based Turn-ON/OFF fluorescent
sensors. Particularly, F-IDAs have been found valuable in pattern-based recognition,
where slightly different multiple sensors are constructed from diverse receptors simply
by swapping fluorescent indicators in and out of receptors or even varying the
concentration ratio. These F-IDAs offer huge potential to develop proficient optical
sensors from numerous supramolecular receptors and imply the effective molecular
recognition event via competitive assay of receptors with an indicator and an analyte.
Besides conceptual and mechanistic details, authors have ensured the significance of FIDAs in the recognition of biologically and environmentally essential cationic, anionic,
and neutral analytes through various examples.
Keywords: Aggregation-induced emission, Amino acids, Biomarker, Drug, Explosive, Emission, Enhancement, Fluorescent indicator displacement assay, Fluorophore, Fluorescent indicator, Fluorescent chemosensor, Quenching, Quencher, Receptor Turn-ON, Receptor, Sensor, Selective, Sensitive, Turn-OFF.
