Vascular lesions compound effects on the clinical demented state in patients with
Alzheimer disease [122]. A given degree of dementia in Alzheimer disease patients suffering from
concomitant ischemic lesions in the cerebrum is associated with lesser numbers of neurofibrillary
tangles and neuritic plaques. This synergistic effect of ischemic lesions with cognitive decline in
Alzheimer patients correlates also with the presence often of congophilic angiopathy. A particular
aspect of ischemic lesions is the association of Alzheimer disease in patients with biochemical
markers for cerebrovascular disease.
