Hypotheses and Dynamics in the Pathogenesis of Neurodegenerative Disorders


Author(s): Lawrence M. Agius

Pp: 57-70 (14)

DOI: 10.2174/978160805032110901010057

* (Excluding Mailing and Handling)


Integral constitutional events in neurofibrillary degeneration relate particularly to the multiphosphorylation sites that discretely segregate molecules in a loosely bound structure present intraneuronally. It is significant that neurofibrillary tangles correspond to spread of disease involvement in Alzheimer brains. It would further appear that the further progression of these lesions would significantly constitute a variable correlate of the senile plaque load.

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