Integral constitutional events in neurofibrillary degeneration relate particularly to the multiphosphorylation
sites that discretely segregate molecules in a loosely bound structure present
intraneuronally. It is significant that neurofibrillary tangles correspond to spread of disease
involvement in Alzheimer brains. It would further appear that the further progression of these lesions
would significantly constitute a variable correlate of the senile plaque load.
