Hypotheses and Dynamics in the Pathogenesis of Neurodegenerative Disorders


Author(s): Lawrence M. Agius

Pp: 36-46 (11)

DOI: 10.2174/978160805032110901010036

* (Excluding Mailing and Handling)


Etiology and pathogenesis of dementing illness is largely resolvable in terms of consequences of an advancing age that promotes the actual progression as assessed by the sequential development of lesions cardinal to the neuronal circuitry involvement. One might view the dynamics of such sequences as a contributing role in the actual evolution of lesions that centrally manifest as neuronal pathophysiology. It is only in terms beyond the actual neuropathologic lesions that an endstage consequence is dominated by irreversible transforming features in the transport mechanics of both injury and compensation of neuronal function.

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