Abstract
Heterocyclic compounds have provided significant contributions to the field
of medicinal chemistry. Pyrazole and pyrazoline are a class of five-membered two
adjacent nitrogen-containing compounds that are integral parts of a large number of
commercial anti-inflammatory drugs. After an initial introduction to inflammatory
response, mechanism involved therein, the chapter compiles recent synthetic schemes
along with in-vivo and in-vitro studies of pyrazole and pyrazoline derivative as antiinflammatory compounds on various established and recently recognized molecular
targets.
Keywords: Anti-inflammatory agents, COX-1, COX-2, LOX, Carrageen paw edema, Cathepsins, Pyrazole, Pyrazoline.
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