Pyrimidine and Pyrimidinone Derivatives as Anti-Inflammatory Agents

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Abstract

Heterocyclic compounds are one of the most significant sources of bioactive molecules. Pyrimidines and pyrimidinones are a class of nitrogen-containing heterocyclic compounds with significant biological activities. Among the different applications of these compounds in medicinal chemistry, their anti-inflammatory activities have attracted the attention of the scientific community to explore their chemistry. Some of these derivatives have been found to inhibit the production of proinflammatory cytokines and chemokine enzymes, which are involved in the recruitment and activation of immune cells at sites of inflammation. The chapter outlines the range of methods available to create different pyrimidine and pyrimidinone derivatives along with their anti-inflammatory activities.

Keywords: Anti-inflammatory agents, Biginelli reaction, Biological activity, Dihydropyrimidinones, Drug discovery, Heterocyclic compounds, Inflammation, Medicinal chemistry, Pharmaceuticals, Pyrimidines and pyrimidinones.