Although human experimentation has greatly increased our understanding of
the human body and diseases, there are still occasions when limits of morality are
crossed during clinical trials. Illiteracy, poverty, corrupt health practitioners, and lack
of law enforcement in developing countries have led to an increase in the exploitation
of people as guinea pigs for trial purposes. These unethical clinical trials in Third
World countries have caused an inferiority complex and a general mistrust in the
healthcare system. It is the duty of the physician and scientists involved in medical
research to protect the life, health, and integrity of research subjects, for which strict
regulations are a necessity.
Keywords: Bioethical principles, Causative factor, Effects, Healthcare sector, Institutional review board, Mortality rates, Prevalence, Suggestions, Third-world countries, Third world countries, The belmont report, The declaration of helsinki, The nuremberg code, Unethical clinical trials.
