The skin is the largest organ in the body that provides protection. When a
wound occurs, the skin structure and its function are damaged, and it can even
compromise life. Damage repair can occur through two mechanisms: healing and
regeneration. When a scar forms, fibrosis occurs in the area, and the skin appendages,
which include the glands and hair follicles, are lost. In regeneration, the functionality of
the skin is partially or totally recovered. Medicinal plants and their active principles
favor the regeneration of skin wounds because they have direct effects on the different
phases of the process. They favor hemostasis, and modulate inflammation, which
allows the following stages of healing to occur in less time, such as proliferation and
remodeling. They favor hemostasis, modulate inflammation, and that the following
stages of healing to occur in less time (proliferation and remodeling). Natural products
can also reduce the risk of wound infections by having antibacterial activity. However,
the bioavailability of the extracts and their metabolites may be limited, and a solution
to this problem is to integrate them into preparations such as hydrogels, nanoparticles,
nanofibers, and nanoemulsions. Research on the therapeutic properties of various
natural products and their integration into the formulations mentioned above for wound
regeneration is described below according to their effect on epithelialization,
regeneration of epidermal appendages, vascularization, and in some cases their
mechanism of action.
Keywords: Hair follicles, Hydrogels, Nanoemulsions, Nanofibers, Nanoparticles, Natural products, Wound regeneration.
