Damage to different body tissues may occur as a result of trauma, injury, or
disease, which requires therapies to aid their healing through repair or regeneration.
Tissue engineering aims to repair, sustain or recover the function of injured tissue or
organs by producing biological substitutes. Advances in different approaches of dental
tissue engineering, ranging from conventional triad (stem cells, scaffold, and regulatory
signals-based tissue engineering) to modern technologies (3D printing and 4D
printing), further emphasize that there are promising treatment approaches offered by
the dental tissue engineering field to a variety of orofacial disorders, specifically
through the design and manufacture of materials, application of appropriate regulatory
signals and the enhanced knowledge of stem cells application. Inspired by their unique
properties, scaffolds of natural origins, such as chitosan, cellulose, alginate, collagen,
silk, and gelatin, have become a popular source of materials manufacturing that would
simulate the biological environment. Future research should focus on translating
laboratory findings into feasible therapies, i.e., directing basic sciences discovered in
dental tissue engineering into contemporary clinically applicable therapies for orofacial
disorders.
Keywords: Biomaterials, Chitosan, Dental tissue engineering, Polymer, Polysaccharide-based biomaterials, Protein-based biomaterial.
