Electrospinning is a commonly used approach to fabricate nanofibers of
various morphologies. This method is highly effective and economically feasible,
capable of producing flexible and scalable nanofibers from a wide variety of raw
materials. To construct an ideal nanofiber with the desired morphological properties,
electrospinning parameters involving the process, solution, and ambiance need to be
fulfilled. Electrospun natural and synthetic polymeric nanofibers have recently proved
to be a promising technique for drug delivery systems. Nanofiber-based drug delivery
mechanisms can be utilised to transport drugs to specific locations and for a period of
time to obtain the intended therapeutic outcomes. The use of electrospun nanofibers as
drug carriers in biomedical applications, particularly in transdermal drug delivery
systems, may be impressive in the future. Generally, in this kind of system, the active
agent or drugs are delivered through the skin into the systemic circulation through a
transdermal drug delivery mechanism that is distributed through the skin’s surface.
Therefore, by using electrospun nanofibers as the carrier of drugs for transdermal
delivery, the system can enhance the drug’s bioavailability and achieve controlled
release.
Keywords: Controlled release, Drug carrier, Drug delivery, Electrospinning, Nanofibers, Transdermal.
