Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19

Aromatic Plants, Essential oils, Carminatives, Tea Plants and Expectorant Herbs for the Management of COVID-19

Author(s): Sonal Upadhyay, Ravi Bhushan, Pawan Kumar Dubey, Bashir A Sheikh, Mithun Rudrapal* and James H. Zothantluanga

Pp: 219-232 (14)

DOI: 10.2174/9789815049510123010011

* (Excluding Mailing and Handling)


SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) leads to coronavirus disorder (COVID-19). It was detected in Wuhan City, China, in December 2019 and extended to different provinces in China. The drug discovery strategy that holds the thrust of the COVID-19 pandemic is the existing trial of broad-spectrum antiviral drugs. However, molecular docking combined with chemical synthesis assists in discovering various synthetic agents, above one-third of FDA (Food and Drug Administration)- are naturally occurring products as approved drugs. Natural derivative products from different sources of fungus, plant and marine have been abundant in nutrition/ phytochemicals to prevent various disease discoveries for many diseases’ prevention. There are scarcely any country that is left intact by the coronavirus outbreak. Only the considerable well-known health threat still now requires it to be managed as early as possible. To date, there is no development of drugs or vaccines that have been proven clinically against COVID-19. Various secondary phytoconstituents with antiviral activities have been extracted from medicinal herbs. Different research works have been demonstrated all over the globe to find antiviral medication effectiveness against SARS-CoV-2 in COVID-19 pandemic. The best preventive measures against COVID-19 infections would be searching for the molecules responsible for modifying or disturbing any pathways related to the virus replication cycle. Natural compounds are capable of altering or inhibiting the configuration of the structural protein of (spike glycoprotein), non-structural proteins (3-chymotrypsin-like protease, papain-like protease, helicase, and RdRP) and accessory proteins encoded by the SARS-CoV-2 genome that are required to be investigated.Hence, various natural products and herbal extracts may prove as potent therapeutics in treating the symptoms related to SARS-CoV-2 infection. In this context, we will present some traditional plants/herbs that are found effective against viral activities and reduce the contamination risk by Coronavirus and cure some symptoms of COVID-19, mainly respiratory problems.

Keywords: Aromatic plants, COVID-19, Expectorant plants, Herbal tea, Management of SARS CoV2, Spices.

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