Large surface area, small size, strong optical properties, controllable
structural features, variety of bioconjugation chemistries, and biocompatibility make
many different types of nanoparticles (NPs), such as gold NPs, useful for many
biological applications, such as biosensing, cellular imaging, disease diagnostics, drug
delivery, and therapeutics. Recently, interactions between proteins and NPs have been
extensively studied to understand, control, and utilize the interactions involved in
biomedical applications of NPs and several biological processes, such as protein
aggregation, for many diseases, including Alzheimer's. These studies also offer
fundamental knowledge on changes in protein structure, protein aggregation
mechanisms, and ways to unravel the roles and fates of NPs within the human body.
Keywords: Nanoparticles interactions, Protein interactions, Protein structure.
