Background and Aim: Global advancement is facing a huge threat due to
the increased number of skin cancer cases and potential health-system costs. Perception
of skin cancer prevalence is important for the treatment, prevention strategies, and
administration of medical allowances. In addition to fair and tanned skin, the risk factor
for the development of disease is sedentary lifestyle habits, and the reduction in
physical activities has risen the mortalities worldwide. This effort signifies information
on incidence, risk factors, and mortality rates across six continents.
Methodology: The scientific literature was illustrated to find the correlation between
the risk factors and resulting data to map, the approaches practiced concerning certain
prevention strategies, in particular to alteration in behaviors such as reduction to UV-light exposure, screening and prevention in the progression of the disease.
Results: The incidence of the disease is highest in Australia and New Zealand and
lowest in Asian countries. A global survey was done on disease burden in 2018, in
which signposts Incidence and mortality are 33.3 ASR and 4.8 ASR, respectively, in
New Zealand and 33.6 ASR and 3.2 ASR, respectively, in Australia for melanoma skin
cancer. The resistance of skin cancer to topical chemotherapy has turned the attention
to natural therapeutics, including herbs, plant extracts and nutraceuticals.
Conclusion: In difficult circumstances, a change in adaptive behavior and cognitive
development can reduce the disease burden worldwide. Natural therapeutics can be
used to exert anti-inflammatory, anti-proliferative and anti-tumorigenic by modulating
the signaling pathways and other physiological effects.
Keywords: Apoptosis, Anti-inflammatory, Incidence, Melanoma skin cancer, Mortality, Melanocytes, Non- melanoma skin cancer, Natural therapeutics, preventive approaches, Signaling pathways, Risk factors, UV- radiation exposure.
