The skin is known as the largest organ in the human body as it functions to
regulate the temperature in the human body and acts as the first-line defence. The skin
consists of two layers: the epidermis (the outer layer of skin) and dermis layers (the
inner layer of the skin) occupied by specific skin cells. Whenever the skin barrier is
compromised, the skin heals following four phases: haemostasis, inflammation,
proliferation, and remodelling. Wound healing takes a few weeks for acute wounds,
however it takes a longer period to heal chronic wounds. Chronic wound complication
extends the inflammation phases during the wound healing process and becomes a
significant problem in the healthcare field. Therefore, various treatments were
produced to reduce the healing time in chronic wounds and produce less scarring.
Acellular treatments have gained attention in wound healing research as these
treatments have a lower risk of rejection and are easily obtained through nature or lab.
Acellular treatments include growth factors, bioactive molecules, and peptides that are
clinically proven to have faster healing time and reduce scarring as these treatments are
readily available in the market. Biomaterials have become a novel study in wound
healing research due to their vast potential as alternative treatments for skin wound
healing. Therefore, the chapter discussed the acellular strategies for tissue wound
healing.
Keywords: Functional biomaterials, Skin, Tissue engineering, Wound healing, Wound treatment.
