Methods for Preclinical Evaluation of Bioactive Natural Products

Activity Methods for Polycystic Ovary Syndrome

Author(s): Murside Ayse Demirel, Kevser Taban Akça, Sümeyra Çetinkaya and Ipek Süntar *

Pp: 200-228 (29)

DOI: 10.2174/9789815123043123010009

* (Excluding Mailing and Handling)


Polycystic ovary syndrome (PCOS) is one of the most common gynecological disorders among women of reproductive age. The secretion rate and metabolism of estrogens and androgens are disrupted in patients with PCOS. Patients have systemic inflammation, hyperinsulinemia, hyperandrogenism, and polycystic ovaries. Several experimental models have been developed and studied for the investigation of this disease. These studies aim to explore the pathophysiology of PCOS and new treatment approaches. Some plant extracts and phytochemicals obtained from them are shown to be effective against PCOS in literature. In this chapter, general information about PCOS, plant-based treatment approaches, and activity methods are explained in detail.

Keywords: Animal models, activity methods, gynecological disease, medicinal plants, natural products, polycystic ovarian syndrome.

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