Colorectal cancer (CRC) is the third most common cancer, originating in the
colon and rectal region, leading to abnormal growth in the colon or rectal region. The
gut microbiota plays a critical role in the maintenance of gut homeostasis, and
dysbiosis in the gut microbiota has been associated with CRC pathogenesis. Probiotics
can manipulate the gut microbiota, which can be effective in CRC treatment.
Additionally, probiotics, through the modulation of host immune response, inhibition
of tumor growth, reduction of microbial infection, inhibition of cancerogenic
compounds, and regulation of apoptosis, can become a novel therapeutic option for the
prevention and treatment of CRC. Therefore, this chapter mainly focuses on the
mechanisms of probiotics-based anticancer immunity in CRC, so the existing
knowledge could help in developing a safe and effective treatment for CRC.
Keywords: Apoptosis, B. bifidum, Colorectal cancer (CRC), Dysbiosis, Gut microbiota, L. rhamnosus, L. acidophilus, Probiotics, Short chain fatty acids (SCFAs), Tyrosine kinase.
