Current Cancer Biomarkers

Protein Cancer Biomarkers

Author(s): Sarath S. Joseph, Dan H. V. Tran, Farhadul Islam and Vinod Gopalan *

Pp: 148-179 (32)

DOI: 10.2174/9789815079364123010011

* (Excluding Mailing and Handling)


Cancer is one of the leading causes of death worldwide and it is becoming increasingly important to be able to efficiently identify and map the progression of cancers. The study of the diagnostic, predictive and prognostic value of protein biomarkers has become one of the main aspects at the forefront of cancer research. The diversity of various biomarkers for different cancers and their varying roles in each disease presents a continual challenge for researchers to understand, with new biomarkers still being discovered today. Understanding the role of protein biomarkers ensures patients are diagnosed with greater confidence and helps clinicians with treatment regimes. This chapter aims to discuss the clinical significance of various protein biomarkers in terms of their diagnostic, prognostic, and predictive value in the treatment of their respective cancers.

Keywords: Biomarker, BRCA, Cancer, Calretinin, CD117, Desmin, Diagnosis, ER/PR receptor, GFAP, HER2, Inhibin, Keratin, Protein, Prognosis, Predictive marker, S100 protein, TTF-1.

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