Hepatitis C Virus-Host Interactions and Therapeutics: Current Insights and Future Perspectives

WHO Hepatitis C Elimination Goal by 2030: Feasible or not?

Author(s): Imran Shahid and Qaiser Jabeen

Pp: 370-405 (36)

DOI: 10.2174/9789815123432123010015

* (Excluding Mailing and Handling)


To put an end to hepatitis C from the world, the quality and equity of hepatitis C screening, diagnosis, and treatment must be accessible to everyone infected with the virus, regardless of age, sex, racism, nationalism, and religious differences. If several key strategies are successfully implemented, countries could collectively meet the WHO target of reducing new HCV infections by around 80% by 2030, compared with 2015. But even with successful implementation, the target of reducing HCV mortality by 65% would take until 2032, according to recent data. To evaluate the power of several interventions those help to reach these goals, several transmission models with data from affected countries that comprise hepatitis C patients demographics, virus prevalence in vulnerable populations, current dynamics of prevention programs, the natural history of hepatitis C and its prevalence, and percentages of deaths caused by hepatitis C must be considered. In addition to that, the models to project what it would take to reach the targets would need to change and improve blood safety and infection control, vertical transmission of hepatitis C infection, extending harm reduction services for PWIDs, expanded testing, and increased treatment with DAAs, with intensive improvements in public health care sectors and strong political will in third-world countries where hepatitis C is almost endemic would be required. In this book chapter, we are focusing on the achievements of the GHSS 2016-2021 plan for hepatitis C with their probable implementations in WHO member states as well as cross-cutting priority actions for the next decade.

Keywords: Community engagement, Diagnostic burnout, Digital health, HCV self-testing, HCV micro-elimination model, HCV macro-elimination model, Hepatitis C elimination, Linkage to care, Monitor outcome, Mobile diagnostic units, National framework, Potential program integration, Reflex HCV testing, Scale-up HCV testing, Task-shifting, Universal DAAs coverage, Virus surveillance.

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