Structural modifications of the resveratrol scaffold are valuable tools in order to develop new derivatives with potential biomedical and pharmacological applications. The investigation of the biological properties of resveratrol-derived semisynthetic systems and the study of their structure-activity relationships are attracting growing interest from medicinal chemists and biologists. In this context, the synthesis of novel resveratrol-derived systems characterisaed by elevated molecular complexity is highly sought after. Over the past years, a wide variety of resveratrol derivatives have been prepared and studied for their biological properties. Therefore, a number of stilbenoid-related potential anticancer, antioxidant, antiviral, analgesic, and anti-neurodegenerative systems have been investigated. This chapter focuses on recent studies related to the preparation and the study of semisynthetic resveratrol-derived systems.
Keywords: Antioxidants, Anticancer Agents, Functionalization, Organic Synthesis, Prodrugs, Resveratrol, Stilbenoids, Structural Modifications.
