Implantation
and the continuation of pregnancy occur through a complicated and sophisticated
dialogue, called “cross-talk,” which starts between the embryo and the
endometrium in the early stages of oocyte maturation. This dialogue provides synchronization
of the journey of the embryo to be implanted with the receptive endometrium.
Understanding the activity and function of the hormones and factors involved in
this dialogue will provide an understanding of endometrial receptivity, which
plays a key role in implantation, and the determination of biomarkers specific for
this period. As a result of the development of omics technology, it has become possible
to identify biomarkers specific to endometrial receptivity by performing genomic,
proteomic, and lipidomic analyses of these hormones and factors. The determination
of these biomarkers, their optimization, and making them usable in the clinic
will allow increased success in ART.
Keywords: Biomarkers, Endometrial receptivity, Genomic analysis, Implantation, Lipidomic analysis, Omics, Proteomic analysis.
