Radiotherapy therapy is one of the effective and curative methods for the
treatment of cancer. One of the reasons for the growing popularity and increased
outcome of radiotherapy is attributed to the tremendously enhanced capacity of
detection and imaging quality with the reduced radiation dose. Breast cancer is the
leading cause with the highest percentage incidence in women worldwide and is the
leading cause of cancer death, especially in the developing world. Over 50% of breast
cancer patients have been prescribed radiotherapy during their cancer disease
management. The present chapter discusses a comprehensive approach to the role of
radiotherapy in breast cancer, including the theory, different phases, and types, clinical
aspects as well as the challenges involved in its optimal outcome. Chemotherapy,
hormone therapy, etc., are the primary treatment modalities for breast cancer, outside
of surgery. In this chapter, external beam radiation treatment is mainly discussed.
Keywords: 3-Dimensional conformal radiotherapy, External Beam Radiotherapy, Intensity-modulated radiation therapy, Medical LINAC, Virtual Simulation.