With the rapid advancement, nanoparticles (NPs) based drug delivery
systems have been recognized as expedient over traditional therapeutics for breast
cancer, fostering targeted drug release, long circulation time, reduced toxicity, and
greater bioavailability. Under normal circumstances when this exogenous structure of
nano-scale dimension approaches nearby cells, it evokes early tripping leading to
membrane wrapping and NPs cellular uptake. Tailoring NPs structure for safe and
intended entry into cells is at the core of nano-therapeutics for attaining high-yield
prognostic and therapeutic efficacy. Interestingly NPs uptake is crucial as it unravels
pathway selection and is decisive for the intracellular fate of nano-medicine. Over the
past, it remained a major challenge to target specifically to improve their delivery. A
significant effort has been devoted to understanding the endocytosis of nano-medicine
for efficient intracellular delivery of NPs. Here we present an overview of the different
endocytic pathways used by cells. Novel strategies in NPs design to exploit the uptake
mechanisms to decipher intended uptake and target breast cancer. Current advances
and strategies are deployed to breach these barriers and attain the ultimate vision of
nano-carriers in diagnostics and therapeutics.
Keywords: Endocytosis, Nano-carrier, Nanoparticles, Targeted Therapeutics.
