Applications of bioinformatic methods and high-throughput sequencing
techniques have increased exponentially over the last decade, transforming the way we
understand complex malignancies such as breast cancer. In this chapter, an overview of
recent advances in molecular research in breast cancer using emerging bioinformatics
methods is presented. Learnings from scientific studies that have successfully
integrated and interpreted massive amounts of data generated from various platforms
(multi-omics data) using bioinformatics approaches are also outlined. Additionally,
pan-cancer studies that help identify the differences and commonalities across multiple
cancers are reviewed. We also discuss bioinformatics applications that transform the
way we decipher the OncoGenomic landscape of breast cancer. Finally, this study also
summarizes current publicly available bioinformatics tools and databases for breast
cancer research.
Keywords: Bioinformatics, Genomics, High-throughput sequencing, Multiomics, Next-generation sequencing, Pan-cancer analysis, Transcriptomics.
