Immunoinformatics is currently an emerging field that has accelerated
immunological research to a great extent. It is playing a significant role in antigen
identification, immunodiagnostic development, and vaccine design. The arrival of
genome sequencing with recent advancements in immunoinformatics has provided a lot
of data that can be annotated using databases and tools to reduce the cost required for
antibody and vaccine development, ultimately saving time, cost, and resources. The
selection and identification of immunogenic regions from the pathogen genomes by
computational methods play an important role in devising new hypotheses by a
comprehensive examination of immunologic data composite, which is otherwise
impossible to achieve by using traditional methods alone. Presently, many epitopebased
vaccines, especially multi-epitope vaccines designed employing
immunoinformatics approaches, are successfully trailed and being developed against
pathogens. In this chapter, we provide an outline of the recent progress in the field of
vaccinology and immunoinformatics, enlisted recent tools and databases available for
epitopes prediction, validation, and vaccine design, and give a brief description of the
role of immunoinformatics in vaccine design against recent COVID-19.
Keywords: Computationally designed vaccines, Immunoinformatics, Reverse
vaccinology, Subtractive genomics.
