Niacin is an essential nutrient necessary to the human body for numerous
enzymatic pathways requiring nicotinamide adenine dinucleotide (NAD) and its
derivatives for redox metabolism. Niacin can be deficient despite its fortification in
flour and cereal products. Niacin deficiency can present in several different forms,
although the most known and recognized is pellagra disease. Immediate type
hypersensitivity to nicotinic acid is rare and it was reported with intravenous
administration only. Even allergic contact dermatitis are reported exceptionally and it
occurs mainly with the topical use of nicotinic acid derivatives more than vitamin B3
itself.
Keywords: Allergic Contact Dermatitis, Anaphylactic Shock, Delayed-type
Reaction, Immediate-type Reaction, Niacin, Nicotinamide, Nicotinic Acid,
Vitamin B3-.
