The outbreak of coronavirus disease-19 (COVID-19) across the world has
caused serious health issues in terms of physical and psychological damage to human
health. The spread of this virus was rapid and shortly spread to almost every country in
the world. Due to the high infection rate and occurrence of complications in the
infected individuals, the research and development of anti- COVID-19 drugs became
the utmost necessity of time as no specific drug is available to relieve the clinical
symptoms of COVID-19. We reviewed reliable information on targeted severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) candidate drugs in the present
chapter. Also, we summarized novel insight into the future development of safe,
effective, and less-toxic antiviral drugs available and employed for the management of
COVID-19. Similarly, we focused on antiviral medications under investigation for this
purpose; several medications with different mechanisms of action were noticed for the
treatment of COVID-19.
Keywords: COVID-19, Drug repurposing, Hydroxychloroquine, Remdesivir,
Umifenovir.
