Various applications of SMEDDS are discussed in detail in this chapter,
which include: upgrading the solubility and bioavailability, protection against
biodegradation, effortless production and scale-up, diminishment in inter-subject and
intra-subject inconstancy and food impacts, the capability to convey peptides that are
liable to enzymatic hydrolysis in GIT, no impact on the lipid digestion and
improvement in drug loading capability. Different variables affecting the performance
of SMEDDS formulation are the nature, amount of the drug, polarity of the lipophilic
phase, and a charge on a droplet of emulsion. Globule size, percent transmission, robust
dilution, zeta potential measurement, cloud point estimation, stability studies, in vitro
lipolysis, in vitro drug release assessment, permeability study, etc., are various
evaluation parameters for SMEDDS/LBDDS that are discussed briefly. This chapter
highlights various advantages, evaluation parameters, and marketed products related to
SMEDDS.
Keywords: Digestion of lipids, Enzymatic hydrolysis, Food effect, Globule size,
In vitro lipolysis, Solubility equilibrium.