Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or
coronavirus disease or COVID-19 is a disease that has led to colossal mortality
worldwide. The fast spread of this disease has caused havoc and panic among
individuals, which has further worsened with the unavailability of vaccines or some
proven drug regime. To date, only 12 new antiviral drugs have been approved by the
FDA (8 against hepatitis C virus (2 in combinations for HIV). Thus, it becomes of
utmost importance to identify drugs for new and re-emerging viruses, including the
coronavirus. Considering the quest, we have put forth this book chapter to update
readers about current repurposed and experimental drugs for this novel coronavirus.
The viral lifecycle assisted in providing vital potential targets for drug therapy. The
present chapter also deals with the existing mechanism of action of the drugs, their
category, and clinical data reported.
Keywords: ACE2 inhibitors, Antiarrhythmic, Antibacterial, Anticancer,
Anticoagulants, Antidiabetic, Antifungal, Anti-inflammatory, Antimalarial,
Antioxidant, Antiparasitic, Antiprotozoal, Antiviral, Chelating agents, COVID-
19, Drug repurposing, Natural products, Psychotropics, RAAS-ACE-ARBs
inhibitors, SARS-CoV-2.
