Neurodegenerative disorders (NDs), such as Alzheimer’s disease (AD),
Parkinson’s disease (PD), and Huntington’s disease (HD), are caused by oxidative
stress, inflammation, and proteinopathy. These are further characterized by loss of
neurons and, consequently, impaired cognitive functions. However, the exact
mechanisms of the pathogenesis of these diseases are still unknown. Nowadays, natural
compounds like curcumin, quercetin, resveratrol, and piperine, among others, have
been explored for the treatment and prevention of neurological disorders. There are
various in vivo studies and clinical trials conducted for alleviating neurological
disorders using natural compounds encapsulated in nanocarrier systems. Nanoparticles
such as lipidic, polymeric, quantum dots help to enhance the bioavailability, specificity,
and targeted delivery of these compounds in the brain. Various simple and reproducible
methods are reported to synthesize the nanoparticles in the literature. In this chapter,
we will explore the role of nanotechnology and natural compounds to treat and prevent
neurodegenerative disorders.
Keywords: Nanotechnology, Nanoparticles, Natural compounds,
Neurodegenerative disorders, Targeted delivery
