Integrated microfluidic sensors have been developed with the understanding
of fundamental laws of blood flow and its non-Newtonian properties and the advent of
microfluidic technology to diagnose various diseases. Lab-on-a-chip platforms based
on hemodynamics allow the highly accurate detection of the pathological changes in
the behaviors of blood (i.e., red blood cells, white blood cells, and platelets) and cells.
Hemorheology depends on the complex interactions of immune response and
cardiovascular and other diseases. The nanofluidic systems initiated by flow
characteristics remain insufficient, but the ongoing development of microfluidic and
nanofluidic systems and the identification of key players and risk factors enable the
study of disease onset and progression, thereby leading to a spectrum of clinically
relevant findings.
Keywords: Blood flow, Cell deformation, Drag force, ESR (erythrocyte
sedimentation rate), Image processing, Lab-on-a-chip, Microfluidics, Pressure,
RBC aggregation, Shear stress, Platelet activation, PIV (particle image
velocimetry), Viscosity.
