Aspirin is known to have inter-individual variability in its pharmacodynamic
response. Clinical investigators continue their empirical search for the optimum aspirin
dose to safely prevent athero-thrombosis. Several patient populations have an
accompanied accelerated platelet turnover that is associated with a time-dependent loss
of aspirin efficacy. Increasing the dosing frequency has been shown to elicit better and
more sustained platelet inhibition compared to a dose increase in these patient populations.
This review explores the role of accelerated platelet turnover in aspirin
pharmacodynamics and the benefits of multiple daily aspirin dosing.
Keywords: Antiplatelet, Aspirin, Essential Thrombocythemia, High On-Aspirin
Platelet Reactivity, Platelet Turnover.
