Collagen is a natural constituent of the extracellular matrix of tissues. It is
well known that, when prepared without additives, diluted collagen hydrogels present
poor mechanical properties limiting their use in tissue engineering. Hence, collagen's
structural properties need to be enhanced. For this purpose, this chapter presents an
overview of the recent advances and alternatives developed to improve the mechanical
properties of collagen biomaterials.
Keywords: Biomaterial, Collagen, Crosslink, Fibrils, Hydrogel, Mechanical
properties, Thermal stability, Tissue engineering, Wound healing.
