Decreasing brain metabolism is a substantive cause of cognitive
abnormalities in Alzheimer´s Disease (AD), although this hypo-metabolism is poorly
understood, i.e. is not known if it is primary or secondary. Neuron ion homeostasis and
thereby synapsis are a crucial and highly energy demanding processes, and one of the
hallmarks of AD is the loss of synapsis in defined regions of the brain. Until today,
alterations in mitochondrial energy supply have been considered the main concern due
to in aging rat neuron model, mitochondria are both chronically depolarized and
produce more reactive oxygen species with age. Thereby, impoverished mitochondrial
function has been actively studied trying to reverse and recover ATP generation.
Today, after more than 100 years that Alois Alzheimer described Augusta D., patients
still die in the same way, in spite multiple treatments, multiple theories, multiple
studies and unfruitful clinical trials.
We believe that the unraveling of the unsuspected intrinsic property of melanin to
transform visible and invisible light into chemical energy through the dissociation of
the water molecule, as chlorophyll in plants, will mark a before and after, this is: a new
frontier, in the understanding and treatment of the nightmare of the XXI century:
Alzheimer´s Disease.
Keywords: Alzheimer, Energy, Hydrogen, Light, Melanin, Neurodegeneration,
Synapsis.
