The skin and liver are the most common organs affected by the side effects
of drugs. Drug-related damage to the skin and subcutaneous tissue is presented in detail
in this chapter. Benign lesions include contact dermatitis and eczematous eruptions.
Severe drug-induced injuries include Stevens-Johnson syndrome (SJS), toxic epidermal
necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS
syndrome), acute generalized exanthematous pustulosis, bullous dermatoses and other
hypersensitivity syndromes. The specific characteristics and responsible agents of these
conditions are offered in tables in this chapter, and particular types of drug-induced
lesions are also presented. A significant part of the chapter focuses on the effects of
targeted cancer therapies on the skin and subcutaneous tissue. Granulomas and
vaccine-induced lesions are also examined.
Keywords: Adverse drug reaction, Allergy, Antibody, Contact dermatitis,
Dermatosis, DRESS syndrome, Eczema, eruption, Hyperpigmentation,
Hypersensitivity, Iatrogenic, Pustulosis, Stevens-Johnson syndrome, Toxic
epidermal necrolysis, Vitiligo.
