In this chapter, we review the current concepts about Nesfatin-1 as a new
anti-obesity treatment and evaluate the existing issues about this knowledge and the
available literature. The intent is to inform clinicians about Nesfatin-1 as a new kind of
anti-obesity treatment and make a rational decision based on this perspective as
possible clinical application. It can be potentially helpful in the therapy of metabolic
disorders and obesity of various origins. In fact, the details of nesfatin-1 physiology
could be clarified, and it may be considered suitable in the future as a potential drug in
the pharmacotherapy of obesity, due to its anorexigenic effects, and as a new potential
modulator of appetite in the therapy of eating disorders such as anorexia nervosa by
using selective nesfatin-1 antagonists. Therefore, further progress of pharmacological
researches in this field is still very limited. Further research on this topic certainly merit
attention.
Keywords: Drug treatment, Eating disorders, Feeding behaviour, Nesfatin-1,
Obesity.
