Radiation has been implicated in causing deleterious effect including cancer. Radiation exposure cause mutations, damage to the hematopoietic, gastrointestinal or central nervous systems which are critical causing adverse health effects. Hence, there is an urgent need to prevent such effects. A majority of phytochemicals have potential chemopreventive efficacy with relative less toxicity. Specifically, the utilization of these natural plants as modifiers of the radiation reaction is accepting extensive considerable attention. In this current review, we summarize the antimutagenic and anticancer effects of some selected natural phytochemicals including Amaranthus, Bael, Angelica, Rhamnoides, Haloil, Ginseng, Moringa, Biophytum etc against radiation induced damage.