Abstract
The carcinogenicity associated with PAH contamination in the aquatic environment has been a topic of prime importance since neoplasia was described in fish living in multi-sources contaminated areas, 50 years ago. Since then, a whole array of studies were conducted in order to better characterize the fate of PAHs, their bioavailability for biota and their effects in term of neoplastic lesions. Genotoxicity assessment is at the heart of the matter, as benzo[a]pyrene, the leader of PAHs, is described as ubiquitous genotoxic and carcinogenic compound, acting in particular by the occurrence of reactive diol metabolite that forms DNA adducts. The causal relationship between exposure to PAHs and occurrence of neoplasia in organisms involves to explore the biological plausibility of the association. Biomarkers of genotoxicity/mutagenicity are a central part of tools that measure the biological plausibility. DNA adducts and DNA strand breaks are lesions that can be advantageously used in sentinel organisms.
Keywords: DNA, DNA adducts, Genotoxicity, Neoplasia, Polycyclic aromatic hydrocarbons (PAHs).
Related Books
A Primer on Earth Pollution: Pollution Types and Disposal
Air Pollution: Economic Modelling and Control Policies
Application of Adsorbents for Water Pollution Control
Assessment and Mitigation of Indoor Radon Problem: A Case Book for Radon Professionals
Changing Landscapes in Urban British Churchyards
Environmental Zeolites and Aqueous Media: Examples of Practical Solutions
Famous Planet Earth Caves
Famous Planet Earth Caves
Environmental Issues for the Twenty-First Century and their Impact on Human Health
Flood Risk Assessment and Management