Abstract
Checkpoints regulate the normal progression of the cell cycle. Disturbance in the normal function of these checkpoints can induce genomic instability, which is associated with cancer initiation. One such form of instability, aneuploidy, can result from alterations of cell cycle checkpoints, and can induce large imbalances in gene copy number. These imbalances could, in turn, alter the expression of gene products involved in cancer development.
Keywords: Aneuploidy, CELL CYCLE REGULATION, Cell Cycle Kinases, CENTRIOLE
Current Genomics
Title: Cell Cycle Checkpoint Genes and Aneuploidy: A Short Review
Volume: 2 Issue: 2
Author(s): William G. Kearns and Johnson M. Liu
Affiliation:
Keywords: Aneuploidy, CELL CYCLE REGULATION, Cell Cycle Kinases, CENTRIOLE
Abstract: Checkpoints regulate the normal progression of the cell cycle. Disturbance in the normal function of these checkpoints can induce genomic instability, which is associated with cancer initiation. One such form of instability, aneuploidy, can result from alterations of cell cycle checkpoints, and can induce large imbalances in gene copy number. These imbalances could, in turn, alter the expression of gene products involved in cancer development.
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Cite this article as:
Kearns G. William and Liu M. Johnson, Cell Cycle Checkpoint Genes and Aneuploidy: A Short Review, Current Genomics 2001; 2 (2) . https://dx.doi.org/10.2174/1389202013350931
DOI https://dx.doi.org/10.2174/1389202013350931 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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