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Abstract
Proteolytic enzymes have been implicated as the pathological agent in a number of disease states. For this reason proteases are attractive therapeutic targets. Phage display of peptide libraries can be used to identify peptides that may be used either directly as inhibitors or serve as leads in the generation of prodrugs and peptidomimetics.
Keywords: Phage Display, Protease Ligand, peptidomimetics, Plasma kallikrein, chymotrypsin, allosteric mechanism
Current Pharmaceutical Biotechnology
Title: Phage Display as a Tool for Protease Ligand Discovery
Volume: 3 Issue: 1
Author(s): Andrew E. Nixon
Affiliation:
Keywords: Phage Display, Protease Ligand, peptidomimetics, Plasma kallikrein, chymotrypsin, allosteric mechanism
Abstract: Proteolytic enzymes have been implicated as the pathological agent in a number of disease states. For this reason proteases are attractive therapeutic targets. Phage display of peptide libraries can be used to identify peptides that may be used either directly as inhibitors or serve as leads in the generation of prodrugs and peptidomimetics.
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Cite this article as:
Nixon E. Andrew, Phage Display as a Tool for Protease Ligand Discovery, Current Pharmaceutical Biotechnology 2002; 3 (1) . https://dx.doi.org/10.2174/1389201023378526
DOI https://dx.doi.org/10.2174/1389201023378526 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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